Access to COGA Data

Several mechanisms are available to obtain COGA data:

The NIAAA/COGA Website is used by authorized researchers to access COGA data.  The COGA families used for the earlier genetic linkage studies are available.  When a scientific collaborator is approved by NIAAA, we send a CD with the pedigree plots and information on how to log in.  The microsatellite linkage data can be downloaded.  In addition to the genetic data, there is an EpiData link that makes the full set of interview data available (the genetic data contains only the subset of families useful for linkage – i.e., the densely affected sample). DNA and raw EEG data may be requested from that website.  It should be noted that the subject ID available on the NIAAA/COGA web site is randomized and different than the ID used by COGA investigators.

The link to the website is https://niaaagenetics.org and instructions for access can be found at Collaborative Studies on Genetics of Alcoholism (COGA) Study.

 

dbGaP: COGA has transmitted GWAS genotypic data to NCBI (National Center for Biotechnology Information)  as part of dbGaP (database for genotypes and phenotypes).   Investigators request these data by following the instructions at the dbGaP site.

The data from the case control GWAS are available along with extensive documentation: phs000125.v1.p1, CIDR: Collaborative Study on the Genetics of Alcoholism (COGA).  COGA harmonized the demographic and alcohol sections of the SSAGA-I and SSAGA-II to a single set of variables:

CIDR: Collaborative Study on the Genetics of Alcoholism Case Control Study

Data from the EU fGWAS sample are also available. These are GWAS data in extended European families:

The Collaborative Study on the Genetics of Alcoholism (COGA)

A version of the COGA case/control data harmonized with data from studies of cocaine and nicotine dependence (SAGE) is also available:

Study of Addiction: Genetics and Environment (SAGE)

In addition, GWAS data from an African American set of extended families is being processed at dbGaP and will be available in the near future.  Finally, other COGA families will be part of the SmokeScreen project and will go to dbGaP when completed.  Smokescreen is comprised a large set of studies focused on substance abuse.

 

Genetic Analysis Workshop 14 (GAW14): A description of the COGA GAW14 data can be found at: www.gaworkshop.org. Send a request to Dr. Jean MacCluer, Texas Biomedical Research Institute, at jean@txbiomedgenetics.org. The request should include a short abstract of the project. Dr. MacCluer will forward the request to the COGA Proposal Review Committee. The review process generally takes 1-2 weeks. Data will be made available through Dr. MacCluer.

 

COGA Proposal Review Committee (Chair: Laura Bierut, M.D.)

  • Collaboration with a COGA Investigator: Contact the COGA investigator who you are interested in working with. The COGA investigator will send a request to the COGA Proposal Review Committee. The request should include a short abstract of the project, what data specifically will be needed for the project, and plans to include COGA investigators as co-authors on any resulting publications. The review process generally takes 1-2 weeks.
  • Published SNP Results: Send a request to the COGA Proposal Review Committee that includes a short abstract of the project and a description of the specific data being requested. Requests should be emailed to Dr. Laura Bierut at laura@wustl.edu, with a cc to Sherri Fisher at sherri@wustl.edu. The review process generally takes 1-2 weeks.